Lilemong tsa morao tjena, lipatlisiso kaBenzylamino Acids(Benzylation ea Amino Acids) e hohetse tlhokomelo e atileng. Benzylamino acid ke mokhoa oa ho kopanya lik'hemik'hale, o ka finyellang liphetoho tse sebetsang ka ho hlahisa lihlopha tsa benzyl ka limolek'hule tsa amino acid, 'me e na le menyetla e pharaletseng ea tšebeliso. Li-amino acid ke lintho tsa motheo tsa ho haha liprotheine, 'me thepa ea tsona le libopeho tsa tsona li bohlokoa mosebetsing oa liprotheine. Ka ho hlahisa lihlopha tsa benzyl, thepa ea physicochemical ea limolek'hule tsa amino acid e tla fetoloa, ka hona e atolose ts'ebeliso ea eona mafapheng a bongaka, saense ea lintho tse bonahalang le organic synthesis.
Lefapheng la bongaka, lipatlisiso tse mabapi le phenylmethyl amino acid e sebelisoa haholo ho kopantseng lithethefatsi. Bokhoni ba eona ba ho hlahisa lihlopha tsa benzyl bo fana ka limolek'hule tsa lithethefatsi ka sebopeho se tsitsitseng le monyetla oa ho ntlafatsa ho monyela ha bona. Hydrophilicity le lipid solubility ea limolek'hule tsa lithethefatsi li ka fetoloa ka ho hlahisa lihlopha tsa benzyl, ka hona ho ntlafatsa ts'ebetso ea bona ea meriana le bioavailability. Sena se fana ka menyetla e mengata bakeng sa nts'etsopele ea lithethefatsi tse ncha le ho khothaletsa boqapi le nts'etsopele lefapheng la bongaka. Ho feta moo, phenylmethylamic acid e boetse e na le mefuta e mengata ea lisebelisoa tse ka sebelisoang lefapheng la mahlale a thepa.
Ka ho laola maemo a ho kopanya, lisebelisoa tsa polymer tse nang le mesebetsi e itseng li ka lokisoa. Kenyelletso ea lihlopha tsa benzyl e ka fetola tšebetso ea bokaholimo le thepa ea mochini, ka hona ea ntlafatsa ts'ebetso le ts'ebetso ea lisebelisoa. Sena se na le litlamorao tsa bohlokoa bakeng sa nts'etsopele ea masimo a kang lisebelisoa tsa betri, li-catalyst le li-sensor. Ntle le moo, nts'etsopele ea mokhoa oa p-benzyl amino acid e boetse e phetha karolo ea bohlokoa ho organic synthesis. Ba sebelisa mokhoa ona, bafuputsi ba ka fetola sebopeho sa limolek'hule tsa amino acid ka nepo ho kopanya metsoako ea lintho tse phelang ka mesebetsi e itseng, joalo ka li-intermediate tsa lithethefatsi le limolek'hule tse sebetsang. Sena se fana ka sethala se pharaletseng bakeng sa k'hemistri ea maiketsetso le ho khothaletsa nts'etsopele ea k'hemistri ea tlhaho.
Hona joale, letoto la lintlafatso tsa bohlokoa li entsoe lipatlisisong tsa p-phenylmethylamino acid. Ka lehlakoreng le leng, mabapi le mekhoa ea ho kopanya, bafuputsi ba lula ba ntlafatsa maemo a karabelo le litsamaiso tsa catalyst ho ntlafatsa katleho ea karabelo le khetho. Ka lehlakoreng le leng, mabapi le masimo a kopo, mokhoa oa phenylmethylamino acid o 'nile oa sebelisoa haholo ho sibolloa ha lithethefatsi le saense ea lintho tse bonahalang,' me o fihletse letoto la liphello tsa bohlokoa. Ka mantsoe a mang, lipatlisiso le tšebeliso ea p-phenylmethylamino acid li tla kenya letsoho ho nts'etsopele ea mahlale le thekenoloji. Tšebeliso e ncha ea mokhoa ona ha e khothalletse nts'etsopele ea lefapha la bongaka feela, empa hape e tlisa katleho e ncha le mekhoa e mecha litabeng tsa saense ea thepa le motsoako oa manyolo. Ho lumeloa hore ka boiteko ba bafuputsi ba bangata, tšebeliso ea phenylmethylamino acid e tla bontša tebello e pharaletseng nakong e tlang.
Nako ea poso: Aug-10-2023
